Candida Endophthalmitis

What is Candida Endophthalmitis?

Candida Endopthalmitis is an visual disease that is caused by pathogens which mainly attack the ocular regions, mainly the vitreous and the anterior chambers of a person’s eye. The ocular pathogens include Candida, Cryptococcus. Yeast and mould that are the two forms of diphasic fungi are also some of the unicellular ocular pathogens.


Candida Endophthalmitis
Image showing growth of Candida Endophthalmitis spots within the eye.


Candida Endophthalmitis is mainly divided into two groups:

  • Endogenous Candida Endophthalmitis – A systemic infection due to fungal attack can represent the intraocular, which can get scattered and disseminated. The Candida and Aspergillus species of the fungi mainly causes such type of infection. The main causes that could trigger Endophthalmitis include malignancy, diabetes, suppression of the immune system, trauma, abuse through intravenous drugs, haemodialysis, and the disease can also result from any surgery in the abdomen or if the person suffers from hyper-alimentation for a long period of time. All this comprises of the Endogenous Candida Endophthalmitis caused by the fungal infection.

  • Exogenous Candida Endophthalmitis – Another form of endophthalmitis is Exogenous Candida Endophthalmitis which are secondary or occur in the case of any trauma or after any recent critical surgery. After any intraocular surgery or if the person goes through any trauma, after which many a times the person gets infected through the species of fungi like Sporothrix, Paecilomyces


Endogenous Candida Endophthalmitis in Case Studies:

Over the last few decades the occurrence of the endogenous Candida Endopthalmitis has increased abruptly and it infects the intraocular part of our body severely. The disease is primarily caused by the fungal spices Candida albicans. The process of treatment includes regular observation of the ocular parts and the new findings, according to those the proper medication is followed which includes many antifungal drugs and in some cases patients also go through vitrectomy. There are chances of the ocular infections further increasing if the there are any specific factors that can make someone susceptible to the infections.

So we see that it is very important for a person to maintain his neat and clean hygiene and stay away from any kind of dust or foreign particles.

According to study, some men were identified to be having endogenous Candida endophthalmitis after an Candida infection in the urinary tract of the person was detected. The result was that the disease at times leads to a systemic infection and causes blindness to the person in some worst and advanced cases. There are also cases in which the disease had not been properly diagnosed and it leads to serious inflammation in the ocular regions of the eye. No examination for any kind of dilation in the fundus was performed. Vitreal and retinal lesions are caused if these kinds of infections are left untreated and the consequences can be threatening.

This study shows that cases of Candida in the urinary tract or other invasive areas, may spread the Candida yeast to the eye region and cause Candida Endophthalmitis. So it becomes clear to us that when such fungal infections are experienced in the eyes or the urinary tract, then it is very important to diagnose the illness quickly, as early as possible and start the treatment to avoid further complications of the infection, as the infection is highly prone to get worse over time when left untreated.


Treatment of the Disease

In the disease Candida Endophthalmitis, the eyes of the patient are potentially damaged due to the intraocular infection caused by the pathogens which reach the eye through the blood stream. But many scientists have researched in the field of medical science to find out new techniques and medicines which can cure the bacterial endogenous candida endophthalmitis, and there have been positive results in past treatments.

Beneficial results can be achieved by systemic antibiotics in the eye when the barrier between the blood and the ocular gets disrupted. The systemic antibiotics are supplied with vitrectomy and other antimicrobials that are intravitreal that helps to set up a vitreous and prominent involvement. The intravitreal antibiotics that are mostly preferred presently are: Ceftazidime that are given to the patients not more than 2.25mg or 0.1 ml and the medication: Vancomycin given less than 1 mg in quantity.

According to a recent survey it has been detected that the patients who have undergone the pars plana vitrectomy can retain their vision almost three times more efficiently than those who have not undergone the vitrectomy. The eyes would not require enucleation or evisceration any further. The present medication of the bacterial Candida Endopthalmitis involves the use of wide-spectrum antibiotics which can affect both the gram negative and positive bacteria and other micro-organism. Based on the extraocular infection of the man/women suffering from the disease they should be treated with systematic antibiotics like cephalosporins, ciprofloxacin, vancomycin etc. for almost three to four weeks on average.


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Candida Endogenous Fungal Endophthalmitis – Optometry Journal – 2007 – by Najmi NG, Song HF, Ober RR

Candida Endophthalmitis – Pharmacotherapy Journal – 2007- by Khan FA, Slain D, Khakoo RA.

A critical diagnosis of Candida Endophthalmitis – Journal of Clinical Ophthalmology – 2007 – by L Au, K Guduru, G Lipscomb, and SP Kelly


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